Jeffrey Panko NP Psychiatry · Patient education
Eszopiclone
Lunesta / Generic tablets
A guide for adults taking eszopiclone.
Follow the directions on your prescription and your provider's recommendations.
Formulations: Oral tablets are taken once at bedtime at the prescribed dose. Older adults and people with liver impairment or interacting medicines may need a lower dose.
What it is used for
Eszopiclone treats difficulty falling asleep or staying asleep. The duration and frequency of use should be reviewed with your provider rather than assumed to be the same for everyone.
How it works
It enhances GABA-A receptor activity, reducing wakefulness. Effects can persist into the next day even when you do not feel very sleepy.
What to expect over time
Sleep may improve from the first few nights. Review persistent insomnia rather than increasing doses yourself. Keep a brief record of bedtime, awakenings, wake time, and next-day alertness.
Taking your medication
- Take immediately before bed with at least seven to eight hours available for sleep.
- Do not take with or immediately after a heavy, high-fat meal because the effect may be delayed.
- Skip a missed dose if the full sleep window is unavailable. Do not repeat a dose that night.
- Avoid alcohol and other unreviewed sleep medicines.
When to get help
Emergency symptoms. Call 911 for slow breathing, inability to wake, or a severe allergic reaction.
Prompt medical advice. Stop the medication and contact your provider immediately after sleepwalking, sleep-driving, or other activities while not fully awake. Report worsening depression or disturbing sleep-related experiences.
If you feel unsafe or have thoughts of self-harm, call 911 or go to an emergency department.
Possible side effects
- Unpleasant or metallic taste
- Headache, dizziness, or dry mouth
- Next-day sleepiness, impaired coordination, or memory problems
Keeping track of treatment
Some side effects resolve with time; others may require a change of medication. Discuss persistent or bothersome side effects with your provider.
Watch for next-day impairment, memory gaps, falls, and unusual nighttime behavior. Serious complex sleep behaviors can occur even with a first dose and without alcohol.
Tolerance, dependence, and misuse are possible. After regular use, consult with your provider before stopping; rebound insomnia and withdrawal may occur.
If you take too much
For a suspected overdose, call Poison Control at 1-800-222-1222 immediately, even if you feel well. Call 911 for a seizure, collapse, trouble breathing, or inability to wake.
Before you start
Do not use if you have had complex sleep behaviors with zolpidem, zaleplon, or eszopiclone. Discuss breathing problems, sleep apnea, liver disease, falls, depression, and substance use.
Discuss pregnancy, pregnancy plans, and breastfeeding with your provider. Treatment decisions should consider both the medication and the condition being treated.
Medicines and interactions
Review all your medications with your provider, including over-the-counter medicines and supplements. Have new medications checked before taking them.
Avoid alcohol and do not combine with another insomnia medicine unless your provider has specifically reviewed the plan. Opioids and other sedatives increase impairment.
Some antibiotics, antifungals, antivirals, and seizure medicines change drug levels. Review grapefruit and all new medicines.
Everyday tips
Keep a consistent wake-up time and allow adequate sleep.
Avoid driving or dangerous work when drowsy, even if you think you slept enough.
Your questions answered
What if I do something in my sleep?
Stop taking the medicine and contact your provider immediately. Do not restart it after a complex sleep behavior such as sleep-driving.
Can I stop after regular use?
Consult with your provider about a stopping plan. Sleep may briefly worsen, and some people need a gradual reduction. CBT-I can help with ongoing insomnia.
Storage and safety
Keep medication in its labeled container, away from excess heat and moisture and out of reach of children and pets. Do not share it. Ask a pharmacy about disposal of unused medication.
Sources
About this information
Educational handout; does not replace your prescription or provider's recommendations.
Educational inclusion does not mean this medication or its indications are treated at this practice. Review the guide for your exact product with your prescriber or pharmacist.