Clonazepam

Clonazepam treats panic disorder and certain seizure disorders. Some other anxiety uses are off-label. A seizure-treatment schedule should not be changed to occasional use.

It enhances GABA activity, reducing excessive nerve firing. Its long duration can provide sustained effects, but sedation and impaired coordination may also carry into the next day.

Effects can begin after the first dose. The timing and duration depend on the formulation and dose. Sleepiness or impaired coordination may last longer than the relief you notice.

Your provider should review whether ongoing treatment is helping and whether the dose or duration should change. Do not increase the dose when the effect seems weaker.

• Follow the prescribed schedule and dose.
• For a dissolving tablet, use dry hands and let it dissolve in the mouth as directed.
• If you miss a dose, take it when you remember unless it is almost time for the next dose. Then skip it. Do not double a dose.
• Never stop abruptly after regular treatment, especially if used for seizures.

• Sleepiness, slowed reactions, or fatigue
• Dizziness, poor balance, or falls
• Memory problems or difficulty concentrating

Some side effects resolve with time; others may require a change of medication. Discuss persistent or bothersome side effects with your provider.

Watch for daytime sedation, falls, memory changes, and breathing problems. Older adults and people taking other sedatives may be more sensitive.

Physical dependence can develop with regular use. Sudden stopping or a rapid reduction can cause severe withdrawal, including seizures. Dependence is different from addiction, but misuse and addiction are also possible.

For a suspected overdose, call Poison Control at 1-800-222-1222 immediately, even if you feel well. Call 911 for a seizure, collapse, trouble breathing, or inability to wake.

Discuss sleep apnea, lung disease, liver or kidney disease, glaucoma, falls, and any history of substance use problems. Tell your provider about all opioids and other sedatives.

Discuss pregnancy, pregnancy plans, and breastfeeding with your provider. Treatment decisions should consider both the medication and the condition being treated.

Review all your medications with your provider, including over-the-counter medicines and supplements. Have new medications checked before taking them.

Combining a benzodiazepine with an opioid can cause profound sedation, slowed breathing, coma, or death. Use such combinations only under a specifically reviewed treatment plan.

Avoid alcohol. Sleeping pills, sedating antihistamines, muscle relaxants, and other sedatives can increase impairment and breathing risks.

Medicines that affect CYP3A metabolism may change levels. Review grapefruit and all additional sedatives with your provider.

Do not drive until you know how the medication affects you. Avoid driving whenever sleepy or impaired.

Keep medication locked away. Never share it, even with someone who has similar symptoms.

Arrange refills or taper instructions before you run out.

Keep medication in its labeled container, away from excess heat and moisture and out of reach of children and pets. Do not share it. Ask a pharmacy about disposal of unused medication.