Centanafadine

Centanafadine is a treatment for attention-deficit/hyperactivity disorder (ADHD). This guide addresses adult use. Treatment aims to improve attention, organization, and impulse control in daily life.

Availability, October 20, 2026: the manufacturer reports FDA approval, but Simtriyo is still awaiting DEA scheduling and is not yet commercially available. Confirm availability and final prescribing instructions before starting.

Centanafadine reduces the reuptake of norepinephrine, dopamine, and serotonin, increasing their signaling. Its FDA label classifies it as a central nervous system stimulant and includes warnings about misuse and addiction.

Review benefit and tolerability during the first weeks and after dose changes. Track task completion, attention, sleep, appetite, and mood. Do not increase the dose for a demanding day.

• Take once each morning, at about the same time, with or without food.
• Swallow whole, or follow the labeled method for sprinkling the entire capsule contents onto one tablespoon of applesauce or yogurt, or into one tablespoon of orange juice. Consume immediately, then drink water.
• Do not chew the granules, divide the contents, or save a mixture for later.
• A missed dose may be taken within four hours of the usual time. After that, skip it. Take no more than one dose in a day.

• Headache or trouble sleeping
• Reduced appetite
• Nausea, dry mouth, or diarrhea
• Faster pulse or higher blood pressure

Some side effects resolve with time; others may require a change of medication. Discuss persistent or bothersome side effects with your provider.

Have blood pressure and pulse checked before and during treatment. Review weight, appetite, sleep, mood, circulation in fingers and toes, and any new tics.

The label warns about abuse, misuse, and addiction. Its suicidal-thoughts warning specifically concerns pediatric patients; adults should also promptly report major mood or behavior changes.

For a suspected overdose, call Poison Control at 1-800-222-1222 immediately, even if you feel well. Call 911 for a seizure, collapse, trouble breathing, or inability to wake.

Discuss heart disease, high blood pressure, fainting, family history of sudden death, bipolar disorder, psychosis, tics, circulation problems, and substance use.

Do not use with an MAOI or within 14 days of stopping one, or with current or previous pheochromocytoma, a rare adrenal-gland tumor. Severe liver impairment is another reason to choose a different treatment.

Discuss pregnancy, pregnancy plans, and breastfeeding with your provider. Treatment decisions should consider both the medication and the condition being treated.

Review all your medications with your provider, including over-the-counter medicines and supplements. Have new medications checked before taking them.

Other stimulants and medicines that raise blood pressure can add cardiovascular risks. Serotonergic medicines need review. Centanafadine can also increase exposure to caffeine and some other medicines.

Do not consume alcohol at the same time as the dose or for at least two hours afterward; it can speed release from the capsule. Review any alcohol use with your provider.

Plan regular meals and a consistent sleep schedule.

Keep any future supply locked away and never share it. Arrange follow-up rather than changing doses yourself.

Keep medication in its labeled container, away from excess heat and moisture and out of reach of children and pets. Do not share it. Ask a pharmacy about disposal of unused medication.